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DB2313 

Cat. No. M29323

All AbMole products are for research use only, cannot be used for human consumption.

DB2313  Structure
Size Price Availability Quantity
5mg USD 140 In stock
10mg USD 240 In stock
25mg USD 520 In stock
50mg USD 850 In stock
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Quality Control & Documentation
Biological Activity

DB2313 is a potent transcription factor PU.1 inhibitor with an apoptosis of 14 nM. DB2313 disrupts the interaction of PU.1 with target gene promoters. DB2313 induces apoptosis of acute myeloid leukemia (AML) cells, and has anticancer effects.

Chemical Information
Molecular Weight 708.83
Formula C42H41FN8O2
CAS Number 2170606-74-1
Form Solid
Solubility (25°C) DMSO 3.7 mg/mL (ultrasonic and warming and heat to 70°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Xiaofan Tu, et al. Respir Res. Airway and parenchyma transcriptomics in a house dust mite model of experimental asthma

[2] Jiajie Tu, et al. Ann Rheum Dis. PU.1 promotes development of rheumatoid arthritis via repressing FLT3 in macrophages and fibroblast-like synoviocytes

[3] Xiaofan Tu, et al. J Allergy Clin Immunol. Airway and parenchymal transcriptomics in a novel model of asthma and COPD overlap

[4] Shouji Zhang, et al. Mol Ther Nucleic Acids. SPI1-induced downregulation of FTO promotes GBM progression by regulating pri-miR-10a processing in an m6A-dependent manner

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  Catalog
Abmole Inhibitor Catalog




Keywords: DB2313  supplier, Apoptosis, inhibitors, activators

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