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Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots. Dazoxiben inhibits TXB2 production in clotting human whole blood with an IC50 of 0.3 μM and causes parallel enhancement of PGE2 greater than PGF2 alpha greater than 6-keto-PGF1 alpha production. In vivo, Dazoxiben (100 μg/kg, intraperitoneal administration) produces a marked prolongation of the tail bleeding time with 96.8 ± 10.8 secs.
| Molecular Weight | 268.7 |
| Formula | C12H13ClN2O3 |
| CAS Number | 74226-22-5 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Prostaglandin Receptor Products |
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| Terutroban
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| Latanoprost
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