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Danicamtiv (MYK-491, SAR 440181) is a novel and selective cardiac myosin allosteric activator that enhances cardiomyocyte contraction. Danicamtiv selectively enhances cardiac actomyosin activity, the molecular force‐generating unit of the sarcomere, prolonging contraction while preserving actin–myosin detachment, allowing relaxation, and without impacting Ca2+ homeostasis.
| Molecular Weight | 435.42 |
| Formula | C16H20F3N5O4S |
| CAS Number | 1970972-74-7 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Myosin Products |
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| Omecamtiv mecarbil
Omecamtiv Mecarbil is a First-In-Class selective small molecule cardiac myosin activator that directly targets the contractile machinery of the heart, binding and increasing the number of cardiac myosin head regions interacting with actin during contraction. |
| (-)-Blebbistatin
(-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. *The compound is unstable in solutions, freshly prepared is recommended |
| 2,3-Butanedione monoxime
2,3-Butanedione Monoxime (BDM) is a myosin ATPASE inhibitor. 2,3-Butanedione Monoxime is a skeletal and cardiac muscle contraction inhibitor. 2,3-Butanedione monoxime induces sarcoplasmic reticulum Ca2+ release. |
| TR100
TR100 is a specific anti-tropomyosin agent that preferentially disrupts the actin cytoskeleton of tumor cells. TR100 selectively disrupts Tm5NM1/2 containing actin filaments. |
| Blebbistain
(±)-Blebbistatin (BLEB) is a small cell permeable selective myosin II inhibitor which potently relaxed normal detrusor smooth muscle. |
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