Free shipping on all orders over $ 500

Dalazatide

Cat. No. M27762

All AbMole products are for research use only, cannot be used for human consumption.

Dalazatide Structure
Synonym:

ShK-186

Price and Availability

For this product's availability, delivery time and price, please email inquiry@abmole.com directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

Dalazatide (ShK-186) is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease.

Chemical Information
Molecular Weight 4442.08
Formula C184H296N57O55PS7
CAS Number 1081110-69-1
Solubility (25°C) Water
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Anu Tyagi, et al. Proc Natl Acad Sci U S A. Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drυg

[2] Gabor Tajti, et al. Biochem Pharmacol. The voltage-gated potassium channel KV1.3 as a therapeutic target for venom-derived peptides

[3] Qiwen Liao, et al. Drug Discov Today. Cnidarian peptide neurotoxins: a new source of various ion channel modulators or blockers against central nervous systems disease

[4] Peter J Prentis, et al. Toxins (Basel). Sea Anemones: Quiet Achievers in the Field of Peptide Toxins

[5] Eric J Tarcha, et al. PLoS One. Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial

Related Potassium Channel Products
TAK-438

TAK-438 is a novel and potent potassium-competitive acid blocker (P-CAB) with IC50 of 19 nM.
ML133 hydrochloride

ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels.
Doxapram hydrochloride hydrate

Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.
Gliquidone

Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.
Pinacidil monohydrate

Pinacidil monohydrate is known to augment a time-independent outward current in cardiac tissues by activating the ATP-regulated potassium channels.
  Catalog
Abmole Inhibitor Catalog




Keywords: Dalazatide, ShK-186 supplier, Potassium Channel, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.