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Dalantercept

Cat. No. M24570

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Dalantercept Structure
Synonym:

ACE-041

Size Price Availability Quantity
100ug USD 660 In stock
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Quality Control & Documentation
Biological Activity

Dalantercept (ACE-041) is an activin receptor like kinase 1 (ALK1) inhibitor, a ligand trap for bone morphogenetic proteins (BMP) 9 and BMP 10. Dalantercept reduces tumor angiogenesis and delays tumor growth by binding to BMP 9 and BMP 10. As an anti angiogenic agent, Dalantercept has potential applications in persistent or recurrent ovarian cancer, renal cell carcinoma (RCC), and related malignant tumors.

Chemical Information
CAS Number 1186210-24-1
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Ghassan K Abou-Alfa, et al. Oncologist. A Phase Ib, Open-Label Study of Dalantercept, an Activin Receptor-Like Kinase 1 Ligand Trap, plus Sorafenib in Advanced Hepatocellular Carcinoma

[2] Robert A Burger, et al. Gynecol Oncol. Phase II evaluation of dalantercept in the treatment of persistent or recurrent epithelial ovarian cancer: An NRG Oncology/Gynecologic Oncology Group study

[3] Vicky Makker, et al. Gynecol Oncol. Phase II evaluation of dalantercept, a soluble recombinant activin receptor-like kinase 1 (ALK1) receptor fusion protein, for the treatment of recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study 0229N

[4] Shilpa Gupta, et al. Curr Oncol Rep. Activin receptor inhibitors--dalantercept

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Keywords: Dalantercept, ACE-041 supplier, Fusion Proteins, inhibitors, activators

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