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Dac51 is an effective FTO inhibitor with an IC50 of 0.4 μM against FTO demethylation.
Orthop Surg. 2024 May;16(5):1175-1186.
Mechanism of Fat Mass and Obesity-Related Gene-Mediated Heme Oxygenase-1 m6A Modification in the Recovery of Neurological Function in Mice with Spinal Cord Injury
Dac51 purchased from AbMole
| Molecular Weight | 505.27 |
| Formula | C20H17Cl2F3N4O4 |
| CAS Number | 2797619-81-7 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage | 4°C, dry, sealed |
| Related FTO Products |
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| Entacapone
Entacapone is an inhibitor of FTO demethylation with IC50 of 3.5 μM, Entacapone also inhibits catechol-O-methyltransferase (COMT) with IC50 of 151 nM. |
| Rhein
Rhein, also known as cassic acid, is a substance in the anthraquinone group obtained from rhubarb. |
| FB23
FB23 is a potent and selective FTO demethylase inhibitor with an IC50 of 60 nM. FB23 binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity. |
| FB23-2
FB23-2 is a potent and selective FTO inhibitor with an IC50 of 2.6 μM, directly binds to FTO and selectively inhibit FTO's m6A demethylase activity. |
| Meclofenamic acid
Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively. |
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