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Metanephrine is an endogenous metabolite of epinephrine, formed by catechol-O-methyltransferase activity, as well as a biomarker of cancer and can be used to diagnose pheochromocytoma. In addition, Metanephrine is a potent agonist of the trace amine-associated receptor TAAR1.
| Molecular Weight | 233.69 |
| Formula | C10H15NO3 · HCl |
| CAS Number | 881-95-8 |
| Solubility (25°C) | Water: 12 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related TAAR Products |
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| Tryptamine
Tryptamine is a monoamine alkaloid and may play a role as a neuromodulator or neurotransmitter. It is an agonist of hTAAR1. It acts as a non-selective serotonin receptor agonist and serotonin-norepinephrine-dopamine releasing agent (SNDRA). Tryptamine is a selective, blood-brain-penetrating 5-HT4 receptor agonist (EC50=1-3 mM) and an endogenous ligand of the aryl hydrocarbon receptor (AHR) (Kd=10-50 nM). Tryptamine promotes intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs). |
| Ralmitaront
Ralmitaront (RO6889450), a potent and orally active partial agonist of the trace amine-associated receptor 1 (TAAR1), acts as a neuroleptic agent. Ralmitaront can be used for the research of neuro-related diseases, such as schizophrenia (SCZ), schizoaffective disorder, and negative symptoms. |
| Ulotaront HCl
Ulotaront HCl is a first-in-class, orally active, CNS-active TAAR1 agonist for studies related to schizophrenia. |
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