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Cytochalasin D (Zygosporin A) is a cytopermeable actin polymerization inhibitor derived from fungi, which inhibits g-actin -- Cofilin interaction by binding g-actin. Cytochalasin D (Zygosporin A) can also inhibit the binding of Cofilin to F-actin, reduce the release of exosomes and induce YAP phosphorylation. Cytochalasin D is a potent inhibitor of actin polymerization. Cytochalasin D disrupts actin microfilaments. Cytochalasin D activates the p53-dependent pathways. Cytochalasin D inhibits smooth muscle contraction. Cytochalasin D inhibits insulin-stimulated glucose transport.
| Cell Experiment | |
|---|---|
| Cell lines | ScN2a cells |
| Preparation method | ScN2a cells were seeded in 12-well plates (BD Falcon) with a growth medium 1.5×105 cells/well. The cells were treated after 24 h with or without 10 μM cytochalasin D and incubated for a further 24 h. Cytochalasin D was dissolved in DMSO (dimethyl sulphoxide), and thus DMSO (0.1%)-treated cells were used as controls. |
| Concentrations | 10 μM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6N mice |
| Formulation | DMSO |
| Dosages | 50 mg/kg |
| Administration | Tail vein injection |
| Molecular Weight | 507.62 |
| Formula | C30H37NO6 |
| CAS Number | 22144-77-0 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage | Powder -20°C |
[1] Gabor Erdoes, et al. The Dark Side of FIBTEM: Cytochalasin D
[5] R K Chiang, et al. Cytochalasin D reversibly weakens retinal adhesiveness
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