All AbMole products are for research use only, cannot be used for human consumption.
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, inhibits the enlongation and shortening of actin filaments, with Kds of 2.2 nM and 1.4 nM for F-actin in the presence of MgCl2 (2 mM) or MgCl2 (2 mM) plus KCl, respectively. Cytochalasin B (6 μM) increases the myofibrillar fragmentation index (MFI), which is attributed to the intensely breaking of myofibrillar proteins into short segments. Cytochalasin B also accelerates the disruption of actin filaments.
In vivo, Cytochalasin B (10, 25, 50 mg/kg, i.p.) dose-dependently increases the life expectancy of Balb/c mice bearing with P388/ADR leukemias. Cytochalasin B at 50 mg/kg produces 10 % long-term survival in the multidrug resistant P388/ADR cohort, and 40 % long-term survival in the drug sensitive P388/S cohort.
Cell Commun Signal. 2023 Jan 23;21(1):22.
Extracellular matrix stiffness mediates uterine repair via the Rap1a/ARHGAP35/RhoA/F-actin/YAP axis
Cytochalasin B purchased from AbMole
Cells. 2022 Oct 9;11(19):3162.
Crosstalk between Extracellular Matrix Stiffness and ROS Drives Endometrial Repair via the HIF-1α/YAP Axis during Menstruation
Cytochalasin B purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | MDA-MB-231 |
| Preparation method | Morphology and metabolism of human adipose-derived stem cells (hASCs) after 24 h in the presence of different concentrations of cytochalasin B (CB), and after 24 h of recovery time. hASCs were seeded at 4000 cells/cm2 with CB 0.1, 1, and 10 μM, or 0.05% dimethyl sulfoxide (DMSO) (CB vehicle), or without treatment (CTR). |
| Concentrations | 0.1, 1, and 10 μM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | C57B1/1 mice |
| Formulation | - |
| Dosages | 50 mg/kg |
| Administration | i.p. |
| Molecular Weight | 479.61 |
| Formula | C29H37NO5 |
| CAS Number | 14930-96-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Actin-Related Protein Products |
|---|
| CK-636
CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively. |
| CK 666
Ck-666 is a cell-permeable inhibitor (IC50=12 μM) of the Arp2/3 complex, which binds to the Arp2/3 complex and stabilizes the inactive state of the complex, preventing the movement of Arp2 and Arp3 subunits into the active filamentous conformation. |
| CK 869
Ck-869 is an inhibitor of the actin associated protein 2/3 complex (ARP2/3) with an IC50 value of 7 μM. |
| Latrunculin A
Latrunculin A (Latrunculia magnifica) is A toxin obtained from the Red Sea sponge Latrunculia magnifica that binds to actin monocytes and inhibits actin aggregation, inhibiting atP-actin, ADP-pi-actin, Kd values of ADP-actin and G-actin were 0.1, 0.4, 4.7 μM and 0.19 μM, respectively. |
| SMIFH2
SMIFH2 is a fH2 domain inhibitor; prevents actin nucleation. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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