All AbMole products are for research use only, cannot be used for human consumption.
Cycloleucine is antagonist of NMDA receptor associated glycine receptor, with a Ki of 600 μM. Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation. Cycloleucine is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine (4-40 mM) 3 hours blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts.
In vivo, Cycloleucine (0.5-4 µg; intracerebroventrical injection) increases time spent in open arms, open arm entries, and extreme arrivals in rats. Cycloleucine reduces thymus and spleen weights in Semliki Forest virus (SFV) strain A7(74) infected and control mice.
| Molecular Weight | 129.16 |
| Formula | C6H11NO2 |
| CAS Number | 52-52-8 |
| Solubility (25°C) | Water 50 mg/mL |
| Storage | -20°C, protect from light, sealed |
[2] S Amor, et al. Br J Exp Pathol. The effect of cycloleucine on SFV A7(74) infection in mice
| Related GluR Products |
|---|
| AZD6765
AZD6765 is an NMDA receptor antagonist. |
| LY404039
LY404039 is a potent, selective and orally active agonist of recombinant human mGlu2, mGlu3 receptors with Ki of 149 nM, 92 nM respectively. |
| Felbamate
Felbamate(Felbatol) is an anticonvulsant compound used in epilepsy research. |
| CTEP
CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over other mGlu receptors. |
| VU 0361737
VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
