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CX614

Cat. No. M29018

All AbMole products are for research use only, cannot be used for human consumption.

CX614 Structure

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Quality Control & Documentation
Biological Activity

CX614 is a positive variant modulator of AMPA receptors that enhances excitatory postsynaptic potentials (amplitude and duration) by blocking and slowing the inactivation of responses to glutamate and automatically evokes excitatory postsynaptic currents in neuronal cultures. CX614 can be used in the study of psychiatric disorders such as depression.

Chemical Information
Molecular Weight 247.25
Formula C13H13NO4
CAS Number 191744-13-5
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Luiz M Oliveira, et al. Brain Res. Ampakine CX614 increases respiratory rate in a mouse model of Parkinson's disease

[2] Daniel P Radin, et al. Biochem Pharmacol. Stargazin differentially modulates ampakine gating kinetics and pharmacology

[3] Daniel P Radin, et al. Anticancer Res. Oncolytic Properties of Ampakines In Vitro

[4] Hussam Jourdi, et al. J Neurosci. Positive AMPA receptor modulation rapidly stimulates BDNF release and increases dendritic mRNA translation

[5] A C Arai, et al. Mol Pharmacol. Effects of the potent ampakine CX614 on hippocampal and recombinant AMPA receptors: interactions with cyclothiazide and GYKI 52466

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