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CX546 is a selective positive AMPA glutamate receptor modulator. CX546 caused an approximately 2-fold increase in the affinity for radiolabeled agonists, whereas CX516 was ineffective. CX546 enhances cognitive function in rats. Administration of CX546 improved the disrupted LI in mGluR5 knockout mice and facilitated LI in control C57BL/6J mice, given extended number of conditioning trails.
| Molecular Weight | 247.29 |
| Formula | C14H17NO3 |
| CAS Number | 215923-54-9 |
| Solubility (25°C) | Ethanol ≥ 10 mg/mL DMSO ≥ 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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