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CVT-10216 counteracted anxiety in all models except that produced by the 5-HT(2C) agonist, mCPP. CVT-10216 exhibited both acute and prophylactic inhibitions of repeated alcohol-withdrawal-induced anxiety. CVT-10216 increases acetaldehyde after alcohol gavage and inhibits 2-bottle choice alcohol intake in heavy drinking rodents, including deprivation-induced drinking. CVT-10216 also prevents operant self-administration and eliminates cue-induced reinstatement of alcohol seeking even when alcohol is not available (i.e., no acetaldehyde). CVT-10216 prevents alcohol-induced increases in NAc DA without changing basal levels. CVT-10216 does not show rewarding or aversive properties in the CPP paradigm at therapeutic doses.
Phytother Res. 2022 Sep 4.
Calycosin protects against oxidative stress‐induced cardiomyocyte apoptosis by activating aldehyde dehydrogenase 2
CVT-10216 purchased from AbMole
| Molecular Weight | 465.48 |
| Formula | C24H19NO7S |
| CAS Number | 1005334-57-5 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related ALDH Products |
|---|
| 4-Diethylaminobenzaldehyde
4-Diethylaminobenzaldehyde |
| Alda-1
Alda-1 is a potent and selective Aldehyde Dehydrogenase-2 Agonist. Alda-1 activates wild-type ALDH2 and restores near wild-type activity to ALDH2*2. |
| WIN 18446
WIN 18446 is a aLDH1a2 inhibitor, with IC50 of 0.3 μM. |
| NCT-501
NCT-501 is a potent and selective inhibitor of Aldehyde dehydrogenase ALDH1A1, a dehydrogenase that has been found to be elevated in certain cancers and in cancer stem cells. |
| 4-Hydroxynonenal
4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. |
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Products are for research use only. Not for human use. We do not sell to patients.
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