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Curcurbitacin-Iib

Cat. No. M4492

All AbMole products are for research use only, cannot be used for human consumption.

Curcurbitacin-Iib Structure
Synonym:

Cucurbitacin IIb

Size Price Availability Quantity
5mg USD 210 In stock
10mg USD 360 In stock
20mg USD 520 In stock
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Quality Control & Documentation
Biological Activity

Cucurbitacin IIb is the active ingredient in chorioides, which induces apoptosis and has anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α.

Chemical Information
Molecular Weight 520.7
Formula C30H48O7
CAS Number 50298-90-3
Form Solid
Solubility (25°C) DMSO 80 mg/mL
Storage 4°C, protect from light
References

[1] Yuan Liang, et al. Cucurbitacin IIb induces apoptosis and cell cycle arrest through regulating EGFR/MAPK pathway

[2] Dongke Wu, et al. Cucurbitacin IIb improved active chromatin-induced systemic lupus erythematosus via balancing the percentage of Th17 and Treg cells

[3] Heriberto Torres-Moreno, et al. Cucurbitacin IIb from Ibervillea sonorae Induces Apoptosis and Cell Cycle Arrest via STAT3 Inhibition

[4] Heriberto Torres-Moreno, et al. Cucurbitacin IIb, a steroidal triterpene from Ibervillea sonorae induces antiproliferative and apoptotic effects on cervical and lung cancer cells

[5] Yao Wang, et al. Cucurbitacin IIb exhibits anti-inflammatory activity through modulating multiple cellular behaviors of mouse lymphocytes

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Keywords: Curcurbitacin-Iib, Cucurbitacin IIb supplier, Apoptosis, inhibitors, activators

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