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CUR61414

Cat. No. M8320

All AbMole products are for research use only, cannot be used for human consumption.

CUR61414 Structure

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Biological Activity

CUR61414 specifically binds to, and antagonizes the activity of smoothened (Smo) in the hedgehog signaling pathway. CUR61414 inhibits proliferation and induces apoptosis in tumor cells without affecting non-tumor cells.

Chemical Information
Molecular Weight 550.69
Formula C31H42N4O5
CAS Number 334998-36-6
Solubility (25°C) DMSO: 2 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Dorothy Moseti, et al. 25-Hydroxycholesterol Inhibits Adipogenic Differentiation of C3H10T1/2 Pluripotent Stromal Cells

[2] Tatiana Gorojankina, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened

[3] Tracy Tang, et al. Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened

[4] Y Katoh, et al. Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation

[5] Yuriko Katoh, et al. Hedgehog signaling pathway and gastric cancer

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Keywords: CUR61414 supplier, inhibitors, activators

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