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CU CPT 4a is a selective TLR3 inhibitor (IC50 = 3.44 μM in RAW 264.7 cells); suppresses downstream signaling pathways mediated by the TLR3/dsRNA complex, inhibiting TNF-α and IL-1β production in whole cells. Reduces death of crypt cells and improves gastrointestinal syndrome in mice.
| Molecular Weight | 377.82 |
| Formula | C18H13ClFNO3S |
| CAS Number | 1279713-77-7 |
| Solubility (25°C) | 1eq. NaOH 18.89 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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