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CU-3 is the racemate of (5Z,2E)-CU-3. (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells.
| Molecular Weight | 392.47 |
| Formula | C16H12N2O4S3 |
| CAS Number | 861123-84-4 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[2] Andrea Crovetto, et al. Chem Mater. Is Cu3- x P a Semiconductor, a Metal, or a Semimetal?
[3] Matthew Zervos. Materials (Basel). AACVD of Cu3N on Al2O3 Using CuCl2 and NH3
[5] Mahsa Parvizian, et al. Angew Chem Int Ed Engl. The Chemistry of Cu3 N and Cu3 PdN Nanocrystals
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