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CTOP TFA

Cat. No. M10240

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CTOP TFA Structure
Synonym:

D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2

Size Price Availability Quantity
1mg USD 200 In stock
5mg USD 450 In stock
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Quality Control & Documentation
Biological Activity

CTOP TFA is a peptide that acts as a potent and selective μ opioid receptor antagonist, with Ki values of 0.96 and >10,000 nM for μ and δ receptors, respectively. CTOP TFA increases K+ currents in rat locus ceruleus neurons in vitro via a μ receptor independent mechanism.

Chemical Information
Molecular Weight 1176.28
Formula C52H68F3N11O13S2
CAS Number 103429-31-8 (free base)
Solubility (25°C) Water 45 mg/mL
Storage -20°C, protect from light, sealed
References

[1] A Badiani, et al. Brain Res. Intra-VTA injections of the mu-opioid antagonist CTOP enhance locomotor activity

[2] K Gulya, et al. Eur J Pharmacol. Central effects of the potent and highly selective mu opioid antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) in mice

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Keywords: CTOP TFA, D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2 supplier, Opioid Receptor, inhibitors, activators

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