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B7/CD28 interaction inhibitor 1 is a potent B7.1-CD28 interaction inhibitor with IC50 of 50 nM. Blocking B7/CD28 interactions with monoclonal antibodies or soluble receptors results in immunosuppression and enhanced allograft survival, while B7/CTLA-4 blockade results in enhanced antitumor immune responses. The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T cells.
| Molecular Weight | 427.35 |
| Formula | C21H13F4N5O |
| CAS Number | 635324-72-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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