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CTB is a potent p300 histone acetyltransferase activator.
CTB (10, 50, 100, 150, 200, and 250 µM; 10 min) enhances p300 HAT activity of p300 in a dosedependent manner. CTB (50 uM; 24 h) increases p300/CBP activity , and reduces autophagic flux in primary neurons.
CTB induces time dependence apoptosis of MCF-7 cells.
| Molecular Weight | 343.73 |
| Formula | C16H13ClF3NO2 |
| CAS Number | 451491-47-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | 4°C, protect from light |
| Related Histone Acetyltransferase Products |
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| Curcumin
Curcumin (Diferuloyl), a natural phenolic compound, is a p300/CREB binding protein specific inhibitor that inhibits histone/non-histone acetylation and histone acetyltransferase-dependent chromatin transcription. Curcumin inhibited NF-κ B and MAPKs, and had anti-inflammatory, antioxidant, anti-proliferation and anti-angiogenesis effects. Curcumin induces Nrf2 protein stabilization through Keap1 cysteine modification. |
| C646
C646 is a selective inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM. C646 preferentially selective for p300 versus other acetyltransferases. |
| MG149
MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM). MG 149 inhibits KAT8 and blocks PINK1 kinase activity. MG 149 can induce mitochondrial depolarization and promote PINK1 dependent mitochondrial clearance. |
| Remodelin
Remodelin is a novel, potent Acetyl-transferase NAT 10 inhibitor that mediates nuclear shape rescue in laminopathic (LMNA-depleted) cells via microtubule reorganization. |
| Histone Acetyltransferase Inhibitor II
Histone Acetyltransferase Inhibitor II, insulin producing cells capable of secreting blood glucose regulating hormones, specially insulin, in response to physiological signals, method of production of said cells and uses thereof. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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