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CS1

Cat. No. M8557

All AbMole products are for research use only, cannot be used for human consumption.

CS1 Structure

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Quality Control & Documentation
Biological Activity

CS1 is a selective and potent inhibitor of topoisomerase IIα (TopoIIα) that potently inhibits a proliferation of cancer cell lines including MDA-MB-231 and A548 cells, with less toxicity than etoposide. CS1 is a nonintercalating topoisomerase IIα (Topo IIα) inhibitor, which stabilizes the DNA-Topo IIα cleavage complex.

Chemical Information
Molecular Weight 252.26
Formula C16H12O3
CAS Number 1448009-94-6
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kim De Veirman, et al. CS1-specific single-domain antibodies labeled with Actinium-225 prolong survival and increase CD8+ T cells and PD-L1 expression in Multiple Myeloma

[2] Casey W Buller, et al. Roles of NK Cell Receptors 2B4 (CD244), CS1 (CD319), and LLT1 (CLEC2D) in Cancer

[3] Joseph D Malaer, et al. 2B4 (CD244, SLAMF4) and CS1 (CD319, SLAMF7) in systemic lupus erythematosus and cancer

[4] Joseph D Malaer, et al. CS1 (SLAMF7, CD319) is an effective immunotherapeutic target for multiple myeloma

[5] Andr Veillette, et al. CS1, a SLAM family receptor involved in immune regulation, is a therapeutic target in multiple myeloma

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Keywords: CS1 supplier, inhibitors, activators

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