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CRX-527 is a highly specific and potent TLR4 agonist, which displays significantly less toxicity when compared to LPS. CRX-527 activates Toll-like receptor 4 (TLR4). Subsequently, it initiates MyD88- and TRIF-dependent pro-inflammatory signaling cascades. Importantly, CRX-527 does not require the TLR4 co-receptor CD14 for activation of either signaling pathway. CRX-527, along with other AGPs, is less toxic than LPS and importantly retains its immunostimulatory properties.
| Molecular Weight | 1488.04 |
| Formula | C81H151N2O19P |
| CAS Number | 216014-14-1 |
| Solubility (25°C) | DMSO 1 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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