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CRS3123

Cat. No. M27636

All AbMole products are for research use only, cannot be used for human consumption.

CRS3123 Structure
Synonym:

REP-3123

Price and Availability

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Quality Control & Documentation
Biological Activity

CRS3123 is a potent and orally active narrow-spectrum antibiotic. CRS3123 inhibits bacterial methionyl-tRNA synthetase. CRS3123 has potent activity against Clostridium difficile (C. difficile) and aerobic Gram-positive bacteria but little activity against Gram-negative bacteria, including anaerobes. CRS3123 has the potential for the research of C. difficile infections.

Chemical Information
Molecular Weight 513.25
Formula C19H19Br2N3O2S
CAS Number 1013915-71-3
Solubility (25°C) DMSO 100 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Seema U Nayak, et al. Antimicrob Agents Chemother. Safety, Tolerability, Systemic Exposure, and Metabolism of CRS3123, a Methionyl-tRNA Synthetase Inhibitor Developed for Treatment of Clostridium difficile, in a Phase 1 Study

[2] Nicola Petrosillo, et al. Front Med (Lausanne). Novel Antimicrobials for the Treatment of Clostridium difficile Infection

[3] Joseph D Lutgring, et al. Clin Infect Dis. Are Vancomycin Non-Susceptible Clostridioides difficile Strains Emerging?

[4] Eugénie Bassères, et al. Curr Opin Gastroenterol. Novel antibiotics in development to treat Clostridium difficile infection

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Keywords: CRS3123, REP-3123 supplier, Antibiotic, inhibitors, activators

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