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Crotedumab

Cat. No. M24689

All AbMole products are for research use only, cannot be used for human consumption.

Crotedumab Structure
Synonym:

REGN1193; Anti-GCGR Reference Antibody

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Quality Control & Documentation
Biological Activity

Crotedumab (REGN1193) is a fully human IgG4 monoclonal antibody that binds and inhibits glucagon receptor (GCGR), with a KD of 0.1 nM. Crotedumab can be used for the research of diabetes.

Chemical Information
CAS Number 1452387-69-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Derek J Nunez, et al. Diabetes Obes Metab. Glucagon receptor as a drυg target: A witches' brew of eye of newt (peptides) and toe of frog (receptors)

[2] Ana Kostic, et al. Diabetes Obes Metab. A first-in-human pharmacodynamic and pharmacokinetic study of a fully human anti-glucagon receptor monoclonal antibody in normal healthy volunteers

[3] Haruka Okamoto, et al. Endocrinology. Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys

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Keywords: Crotedumab, REGN1193; Anti-GCGR Reference Antibody supplier, inhibitors, activators

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