All AbMole products are for research use only, cannot be used for human consumption.
CRF (bovine) TFA is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM. CRF is released from hypothalamic-pituitary-adrenal (HPA) axis induced by stress, and leads to production of glucocorticoids which down regulate immune responses. CRF also has proinflammatory effects.
| Molecular Weight | 4811.36 |
| Formula | C208H341F3N60O65S |
| CAS Number | 92307-52-3 (free base) |
| Solubility (25°C) | Water |
| Storage | -20°C, sealed |
| Related CRFR Products |
|---|
| Verucerfont
Verucerfont is a corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50s of ~6.1, >1000 and >1000 nM for CRF1, CRF2, and CRF-BP, respectively. |
| Antalarmin hydrochloride
Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist with a Ki of 1 nM. |
| CP-154526 hydrochloride
CP-154526 hydrochloride is a selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1) with a Ki of 2.7 nM. CP 154526 hydrochloride shows selective for CRF1 over CRF2 (Ki = >10 μM). |
| CP-376395
CP-376395 is a CRF1-selective antagonist. |
| Corticotropin-releasing factor (human)
Corticotropin-releasing factor human (Human CRF) stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary. |
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