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Crebanine, an alkaloid from Stephania venosa, induces G1 arrest and apoptosis in human cancer cells. Crebanine exhibits anti-inflammatory activity via suppressing MAPKs and Akt signaling. Crebanine also possesses antiarrhythmic effect. Furthermore, Crebanine can inhibit the PI3K/Akt/mTOR pathway and generate reactive oxygen species, thereby blocking tumour proliferation and migration. In animal studies, Crebanine has also demonstrated central and peripheral analgesic and anti-inflammatory activity.
| Molecular Weight | 339.39 |
| Formula | C20H21NO4 |
| CAS Number | 25127-29-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
| Storage | 4°C, protect from light |
[5] Tanwawan Duangthongyou, et al. Acta Crystallogr Sect E Struct Rep Online. (-)-crebanine
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| Perifosine
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| MK-2206 2HCl
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| Ipatasertib
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