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CP724714

Cat. No. M8103

All AbMole products are for research use only, cannot be used for human consumption.

CP724714 Structure
Size Price Availability Quantity
5mg USD 105 In stock
10mg USD 190 In stock
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Quality Control & Documentation
Biological Activity

CP724714 is a potent and selective inhibitor of HER2/ErbB2 with an IC50 value of 10 nM. CP724714 is >640-fold selectivity against EGFR, and >1000-fold selective against InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met, JNK-2, JNK-3, ZAP-70, CDK-2 and CDK-5 in in vitro kinase assays. CP724714 had antiproliferative effects in a panel of human breast cancer cell lines.

Chemical Information
Molecular Weight 469.53
Formula C27H27N5O3
CAS Number 383432-38-0
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Lan-Yi Wei, et al. Development of the Sensing Platform for Protein Tyrosine Kinase Activity

[2] Atiqur Rahman, et al. Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

[3] Nomie Emeriau, et al. Store operated calcium entry is altered by the inhibition of receptors tyrosine kinase

[4] Lun Dong, et al. Cooperative oncogenic effect and cell signaling crosstalk of co‑occurring HER2 and mutant PIK3CA in mammary epithelial cells

[5] Dongsheng Huang, et al. Cisplatin resistance in gastric cancer cells is associated with HER2 upregulation-induced epithelial-mesenchymal transition

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Keywords: CP724714 supplier, inhibitors, activators

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