All AbMole products are for research use only, cannot be used for human consumption.
CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. CP-640186 inhibites fatty acid synthesis in rats, CD1 mice, and ob/ob mice with ED50s of 13, 11, and 4 mg/kg, and stimulated rat whole body fatty acid oxidation with an ED50 of ~30 mg/kg.
Am J Cancer Res. 2020 Feb 1;10(2):595-609.
Angiopoietin-like 4 deficiency upregulates macrophage function through the dysregulation of cell-intrinsic fatty acid metabolism
CP-640186 purchased from AbMole
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Source | Am J Cancer Res 2020 Feb. Figure 4. CP-640186 (Abmole Bioscience, USA) |
| Method | Western blot | |
| Cell Lines | ANGPTL4-/- mice | |
| Concentrations | - | |
| Incubation Time | - | |
| Results | Another reagent (CP-640186), an ACC1 inhibitor, also decreased the TNF-α and CD86 levels of ANGTPL4-/- macrophages to normal levels. |
| Molecular Weight | 485.62 |
| Formula | C30H35N3O3 |
| CAS Number | 591778-68-6 |
| Solubility (25°C) | DMSO 70 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Acetyl-CoA Carboxylase Products |
|---|
| Olumacostat glasaretil
Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC). |
| CP-640186 HCl
CP-640186 Hcl is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431. |
| PF-05175157
PF-05175157 is a potent Acetyl-CoA carboxylase (ACC1) inhibitor with IC50s of 23.5±1.1 nM (rat) and 27.0±2.7 nM (human). |
| Firsocostat (ND-630)
ND-630 is an ACC inhibitor of human ACC1 and ACC2 with IC50 values of 2.1 and 6.1 nM, respectively. |
| PF-05221304
PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first step of adipogenesis ab initio (DNL). |
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Products are for research use only. Not for human use. We do not sell to patients.
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