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CP-601927 

Cat. No. M29978

All AbMole products are for research use only, cannot be used for human consumption.

CP-601927  Structure

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Quality Control & Documentation
Biological Activity

CP-601927 is a selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist (Ki=1.2 nM; EC50=2.6 μM). CP-601927 shows good brain penetration and antidepressant-like properties.

Chemical Information
Molecular Weight 227.23
Formula C12H12F3N
CAS Number 357425-02-6
Form Liquid
Solubility (25°C) DMSO 200 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hans Rollema, et al. Psychopharmacology (Berl). The contribution of agonist and antagonist activities of α4β2* nAChR ligands to smoking cessation efficacy: a quantitative analysis of literature data

[2] Mark L Weber, et al. Neuropharmacology. Therapeutic doses of antidepressants are projected not to inhibit human α4β2 nicotinic acetylcholine receptors

[3] Sarah N Campion, et al. Birth Defects Res B Dev Reprod Toxicol. Toxicity study in juvenile rats with the α4β2 nicotinic acetylcholine receptor partial agonist CP-601,927

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Keywords: CP-601927  supplier, AChR/AChE, inhibitors, activators

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