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Coumermycin A1 

Cat. No. M30102

All AbMole products are for research use only, cannot be used for human consumption.

Coumermycin A1  Structure
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1mg USD 450 4-7 Days
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Quality Control & Documentation
Biological Activity

Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria. Coumermycin A1 shows anti-orthopoxvirus activity.

Chemical Information
Molecular Weight 1110.08
Formula C55H59N5O20
CAS Number 4434-05-3
Form Solid
Solubility (25°C) DMSO 50 mg/mL (Need ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Arnaud Vanden Broeck, et al. J Med Chem. Structural Basis for DNA Gyrase Interaction with Coumermycin A1

[2] H L Newmark, et al. J Pharm Sci. Coumermycin A1-Biopharmaceutical studies. II

[3] J Fedorko, et al. Appl Microbiol. In vitro activity of coumermycin A1

[4] C M Perronne, et al. Antimicrob Agents Chemother. Treatment of Staphylococcus aureus endocarditis in rats with coumermycin A1 and ciprofloxacin, alone or in combination

[5] M J Ryan. Biochemistry. Coumermycin A1: A preferential inhibitor of replicative DNA synthesis in Escherichia coli. I. In vivo characterization

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Keywords: Coumermycin A1  supplier, JAK, inhibitors, activators

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