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Corylifol A showed an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 value of 0.81 ± 0.15 uM, also inhibited STAT3 phosphorylation induced by IL-6 in Hep3B cells.Corylifol A inhibited SARA PLpro in a dose-dependent manner with IC50 ranging between 4.2 and 38.4 μM
| Molecular Weight | 390.47 |
| Formula | C25H26O4 |
| CAS Number | 775351-88-7 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related STAT Products |
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| Artesunate
Artesunate is a potential STAT3 inhibitor that acts on the small cell lung cancer cell line H69 with an IC50 value of < 5 μM and is also used in antimalarial studies. Artesunate also promotes ROS signaling and lipid peroxidation by increasing the formation of variable iron pools, ultimately leading to iron death in pancreatic cancer cells. |
| NSC 74859 (S3I-201)
NSC 74859 (S3I-201) is a selective Stat3 inhibitor with an IC50 of 86 μM. NSC 74859 (S3I-201) is effective in hepatocellular cancers with disrupted TGF-beta signaling.*The compound is unstable in solutions, freshly prepared is recommended |
| Fludarabine
Fludarabine (NSC 118218) is a STAT1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. Fludarabine markedly inhibited VSMC proliferation in cell culture. Fludarabine also induces significant reduction of STAT-1 phosphorylation, whereas it does not change JAK2 activation. Fludarabine exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. |
| Niclosamide
Niclosamide is an inhibitor of STAT3 with an IC50 value of 0.25 μM. |
| Nifuroxazide
Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells. |
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