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Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system. Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect.
Corticosterone results in a marked reduction in the ability of BMDC cells to prime naive CD8+ T cells in vivo. Corticosterone (0.03 or 1 mg/kg; s.c.; single) downregulates expression of BDNF mRNA in dentate gyrus and CA1 of rats.
| Cell Experiment | |
|---|---|
| Cell lines | PC12 cells |
| Preparation method | PC12 cells were treated with 200 μM of corticosterone in the absence or presence of different concentrations of RES for 24 h. Then, cell viability was measured by Cell Counting Kit-8 assay. Apoptosis of PC12 cells was measured by Annexin V-FITC and Propidium iodide (PI) labelling. The expression of apoptosis-related proteins including Bax, Bcl-2, caspase-3 was determined by western blotting. |
| Concentrations | 200 μM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Male C57BL/6N mice |
| Formulation | Saline containing 0.1% dimethyl sulfoxide (DMSO) and 0.1% Tween-80 |
| Dosages | 20 mg/kg |
| Administration | Subcutaneously |
| Molecular Weight | 346.46 |
| Formula | C21H30O4 |
| CAS Number | 50-22-6 |
| Solubility (25°C) | DMSO 90 mg/mL Ethanol 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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