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Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib dihydrochloride has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib dihydrochloride has superior antitumor activity.
| Molecular Weight | 553.44 |
| CAS Number | 1402152-13-9 |
| Solubility (25°C) | Water 20 mg/mL DMSO 5 mg/mL |
| Storage | 2-8°C, dry, sealed |
[1] Iain Simpson. Ther Deliv. An industry update: the latest developments in therapeutic delivery
| Related PI3K Products |
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AS-605240 is a potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) with an IC50 of 8 nM. |
| BEZ235
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