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Conessine

Cat. No. M8229

All AbMole products are for research use only, cannot be used for human consumption.

Conessine Structure

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Quality Control & Documentation
Biological Activity

Conessine is a plant steroid alkaloid that acts as a potent and specific antagonist of histamine H3 receptors (Ki = 5.37 and 24.5 nM for human and rat receptors, respectively). Conessine is 1860-fold selective for H3 over H4 and does not bind to H1 or H2 receptors. The molecule also binds to the human α2C4 adrenergic receptor (pKi = 7.98).

Chemical Information
Molecular Weight 356.59
Formula C24H40N2
CAS Number 546-06-5
Solubility (25°C) ethanol: ≥2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Juntamanee Jewboonchu, et al. Atomistic insight and modeled elucidation of conessine towards Pseudomonas aeruginosa efflux pump

[2] Hyunju Kim, et al. Conessine Treatment Reduces Dexamethasone-Induced Muscle Atrophy by Regulating MuRF1 and Atrogin-1 Expression

[3] Hyunju Kim, et al. Conessine treatment reduces dexamethasone-induced muscle atrophy by regulating MuRF1 and atrogin-1 expression

[4] Thanyaluck Siriyong, et al. Conessine as a novel inhibitor of multidrug efflux pump systems in Pseudomonas aeruginosa

[5] Hyunju Kim, et al. Conessine Interferes with Oxidative Stress-Induced C2C12 Myoblast Cell Death through Inhibition of Autophagic Flux

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Keywords: Conessine supplier, inhibitors, activators

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