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Coenzyme A is an essential cofactor in all living cells synthesized by Vitamin B5, ATP, and cysteine. Covalent binding of Coenzyme A to peroxidase 5 (Prdx5) results in complete inhibition of peroxidase activity, which can be reversed by DTT reduction. Coenzyme A and its thioester derivatives are key participants in major catabolic, anabolic pathways and regulation of gene expression. Many human pathologies, including cancer, diabetes, and neurodegeneration, are associated with abnormal biosynthesis and homeostasis of Coenzyme A and its derivatives.
| Molecular Weight | 767.53 |
| Formula | C21H36N7O16P3S |
| CAS Number | 85-61-0 |
| Solubility (25°C) | DMSO 50 mg/mL Water 50 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
[2] Ivan Gout. Biochem Soc Trans. Coenzyme A: a protective thiol in bacterial antioxidant defence
[4] Hao Yang, et al. Biochem Soc Trans. Hereditary diseases of coenzyme A thioester metabolism
| Related Metabolite/Endogenous Metabolite Products |
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| 2'-Deoxyinosine
2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond. It is a DNA damage product resulting from the impairment of DNA by reactive nitrogen species. 2′-deoxyinsine can be used as a model compound to study the chemistry of adduct formation and radical chemistry that may affect DNA structures. 2′-Deoxyinosine is used to produce hybridization-sensitive fluorescent DNA probes with self-avoidance ability. |
| Ribitol
Ribitol (Adonitol) is a crystalline pentose alcohol formed by the reduction of ribose. |
| Glycodeoxycholic Acid
Glycodeoxycholic Acid is an endogenous metabolite. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis. |
| Glycolithocholic acid
Glycolithocholic acid, an endogenous metabolite, is a glycine conjugated secondary bile acid. Glycolithocholic acid can be used to study ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH0) and primary sclerosing cholangitis (PSC). |
| 4-Aminohippuric Acid
4-Aminohippuric acid is a typical substrate of organic anion transport systems. 4-Aminohippuric acid is a diagnostic agent, useful in medical tests involving the kidney, used in the measurement of renal plasma flow. |
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