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Coelenterazine

Cat. No. M9267

All AbMole products are for research use only, cannot be used for human consumption.

Coelenterazine Structure
Synonym:

CTZ; CLZN

Size Price Availability Quantity
1mg USD 100 In stock
2mg USD 150 In stock
5mg USD 310 In stock
10mg USD 480 In stock
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Quality Control & Documentation
Biological Activity

Coelenterazine (CTZ) can be catalyzed by luciferases, such as the sea pansy Renilla reniformis (Rluc) and the marine copepod Gaussia princeps (Gluc), which results in emission of blue light. In Gli36-Gluc- or Gli36-Rluc-expressing Gli36 cells, coelenterazine (8 μM/ml) shows a bioluminescence signal.

In vivo, in 4T1-implanted mouse, Coelenterazine detects cancer-associated superoxide anion and used to evaluate the role of superoxide anion in cancer cell biology and its role in pathology.

*The compound is unstable in solutions, freshly prepared is recommended



Product Citations
Chemical Information
Molecular Weight 423.46
Formula C26H21N3O3
CAS Number 55779-48-1
Solubility (25°C) Ethanol 2 mg/mL (Need ultrasonic
DMSO can inactivate Coelenterazine's activity)
Storage -20°C, protect from light, sealed
References

[1] Laura Bronsart, et al. Mol Imaging Biol . Reactive Oxygen Species Imaging in a Mouse Model of Inflammatory Bowel Disease

[2] Bronsart LL, et al. Mol Imaging Biol. Multimodality Imaging of Cancer Superoxide Anion Using the Small Molecule Coelenterazine.

[3] Morse D, et al. Mol Ther. A water-soluble coelenterazine for sensitive in vivo imaging of coelenterate luciferases.

[4] Pichler A, et al. Proc Natl Acad Sci U S A. Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine.

[5] S Bhaumik, et al. Proc Natl Acad Sci U S A . Optical imaging of Renilla luciferase reporter gene expression in living mice

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Keywords: Coelenterazine, CTZ; CLZN supplier, Fluorescent Dye, inhibitors, activators

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