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CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 hydrochloride possesses a high selectivity for iron(III) over others metals.
CN128 hydrochloride (450 μmol/kg; p.o.) exhibits a good iron scavenging efficacy in rat. CN128 hydrochloride (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg.
| Molecular Weight | 295.76 |
| Formula | C15H18ClNO3 |
| CAS Number | 1335282-05-7 |
| Form | Solid |
| Solubility (25°C) | Water 50 mg/mL DMSO 18 mg/mL |
| Storage | 4°C, dry, sealed |
| Related Ferroptosis Products |
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| Deferiprone
Deferiprone is the only orally active iron-chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values. |
| Erastin
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| Lithocholic acid
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