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CMP-5 is a potent and selective PRMT5 inhibitor that is inactive against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity during histone preparation. CMP-5 blocks EBV-driven B lymphocyte transformation but has no effect on normal B cells.
| Molecular Weight | 315.41 |
| Formula | C21H21N3 |
| CAS Number | 880813-42-3 |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] C H Lin, et al. Biochemistry. Why is CMP-ketodeoxyoctonate highly unstable?
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