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Clozapine N-oxide (CNO) is a 5-HT2 serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.
In vivo, after a single intraperitoneal (i.p.) injection of Clozapine N-oxide (1 mg/kg) into mice, Clozapine N-oxide (CNO) plasma levels peak at 15 min and are very low after 2 h. Acutely administered CNO can be metabolically converted to Clozapine in other species such as human and guinea-pig.
JCI Insight. 2025 Mar 18.
The brain-body circuit mediates acute stress-induced anti-inflammatory reflex in bacterial cystitis by suppressing ILC2 activation
Clozapine N-oxide purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | PBMCs |
| Preparation method | The dose-dependent proliferative response of TCC (5 × 10^4/well) was assessed by culturing irradiated EBV-transformed B cells (1 × 10^4/well) with clozapine, N-desmethylclozapine, clozapine N-oxide, or olanzapine (all 0.5–100 μM) for 48 h in triplicate wells at 37°C, 5% CO2. |
| Concentrations | 0.5–100 μM |
| Incubation time | 48 h |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6 mice |
| Formulation | PBS |
| Dosages | 1 mg/kg, twice daily |
| Administration | Subcutaneous injection |
| Molecular Weight | 342.82 |
| Formula | C18H19ClN4O |
| CAS Number | 34233-69-7 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] M Flavia Barbano, et al. Neuron. VTA Glutamatergic Neurons Mediate Innate Defensive Behaviors
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