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CL 82198 hydrochloride is a selective inhibitor of MMP-13 (89% inhibition at 10 μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75. Rescues paclitaxel induced axon degradation and reduces associated neurotoxicity in zebrafish.
| Molecular Weight | 338.83 |
| Formula | C17H23N2O3.HCl |
| CAS Number | 1188890-36-9 |
| Solubility (25°C) | Water 33.88 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related MMP Products |
|---|
| Apigenin 7-O-glucuronide
Apigenin 7-O-glucuronide is an inhibitor of Matrix Metalloproteinases (MMP) with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively. |
| Ilomastat
Ilomastat (GM6001; Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor with Ki values of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM and 0.36 nM for MMPs -1, -2, -3, -7, -8, -9, -12, -14 and -26, respectively. Ilomastat (GM6001; Galardin) reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. |
| Batimastat
Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. |
| NSC 405020
NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP. |
| Marimastat
Marimastat (BB-2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 with IC50 of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM, respectively. |
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