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Ck-666 is a cell-permeable inhibitor (IC50=12 μM) of the Arp2/3 complex, which binds to the Arp2/3 complex and stabilizes the inactive state of the complex, preventing the movement of Arp2 and Arp3 subunits into the active filamentous conformation.
Patent. CN116270617B 2024 Jan 26.
Patent. CN116270617B
CK 666 purchased from AbMole
Patent. CN116270617A 2023 Jun 23.
Patent. CN116270617A
CK 666 purchased from AbMole
| Molecular Weight | 296.34 |
| Formula | C18H17FN2O |
| CAS Number | 442633-00-3 |
| Solubility (25°C) | DMSO 29.63 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Actin-Related Protein Products |
|---|
| CK-636
CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively. |
| CK 869
Ck-869 is an inhibitor of the actin associated protein 2/3 complex (ARP2/3) with an IC50 value of 7 μM. |
| Latrunculin A
Latrunculin A (Latrunculia magnifica) is A toxin obtained from the Red Sea sponge Latrunculia magnifica that binds to actin monocytes and inhibits actin aggregation, inhibiting atP-actin, ADP-pi-actin, Kd values of ADP-actin and G-actin were 0.1, 0.4, 4.7 μM and 0.19 μM, respectively. |
| SMIFH2
SMIFH2 is a fH2 domain inhibitor; prevents actin nucleation. |
| Cytochalasin D
Cytochalasin D (Zygosporin A) is a cytopermeable actin polymerization inhibitor derived from fungi, which inhibits g-actin -- Cofilin interaction by binding g-actin. Cytochalasin D can also inhibit the binding of Cofilin to F-actin, reduce the release of exosomes and induce YAP phosphorylation. |
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Products are for research use only. Not for human use. We do not sell to patients.
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