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Citreoviridin is a mycotoxin and potent inhibitor of mitochondrial ATPase. Citreoviridin inhibits soluble ATPase (KD = 4.1 µM), ADP-stimulated respiration in isolated rat liver mitochondria (KD = 0.15 µM), and ATP-driven reduction of NAD+ by succinate (KD = 2 µM). Citreoviridin has been used to target ectopic ATPase activity in cancer cells in order to modulate the metabolic activity associated with tumorigenesis.
| Molecular Weight | 402.48 |
| Formula | C23H30O6 |
| CAS Number | 25425-12-1 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] John I Pitt, et al. A Concise History of Mycotoxin Research
[4] E M Gause, et al. Binding of citreoviridin to the beta subunit of the yeast F1-ATPase
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