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CINK4

Cat. No. M8505

All AbMole products are for research use only, cannot be used for human consumption.

CINK4 Structure

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Quality Control & Documentation
Biological Activity

CINK4 is a specific inhbitor of CDK4/cyclin D1 complexes (IC50 = 1.5 mM). CINK4 has greater than 50 fold selectivity over CDK1 or CDK2. CINK4 dose-dependently inhibits phosphorylation of retinoblastoma (Rb) and induces G0-G1 cell cycle arrest and apoptosis in cancer cell lines.

Chemical Information
Molecular Weight 456.58
Formula C27H32N6O
CAS Number 359886-84-3
Solubility (25°C) DMSO: 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Chao Su, et al. Tudor staphylococcal nuclease (Tudor-SN), a novel regulator facilitating G1/S phase transition, acting as a co-activator of E2F-1 in cell cycle regulation

[2] Xiang-Hua Zhang, et al. A CDK4/6 inhibitor enhances cytotoxicity of paclitaxel in lung adenocarcinoma cells harboring mutant KRAS as well as wild-type KRAS

[3] Jin Hiruta, et al. Restricted expression of NADPH oxidase/peroxidase gene (Duox) in zone VII of the ascidian endostyle

[4] R Soni, et al. Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4

[5] A Kubo, et al. Searching for selective cyclin-dependent kinase inhibitors to target the retinoblastoma/p16 cancer gene pathway

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Keywords: CINK4 supplier, inhibitors, activators

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