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Cilastatin sodium is a dipeptidase inhibitor (LTDase, leukotriene D4 hydrolase, dehydropeptidase I) that displays a Ki value of 0.11 μM. Inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. Nephroprotective; reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells.
| Molecular Weight | 380.43 |
| Formula | C16H25N2NaO5S |
| CAS Number | 81129-83-1 |
| Solubility (25°C) | DMSO 4 mg/mL Water 8 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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