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Ciglitazone is an effective selective PPARγ agonist (EC50=3 μM). Ciglitazone inhibited the proliferation and differentiation of TH17 cells. Ciglitazone is an oral hypoglycemic agent that has been shown to be active in obese hyperglycemic animal models. Ciglitazone induces apoptosis in opossum renal epithelial cells and simultaneously activates nuclear translocation of P38 MAPK and apoptosis-inducing factor (AIF).
| Molecular Weight | 333.44 |
| Formula | C18H23NO3S |
| CAS Number | 74772-77-3 |
| Solubility (25°C) | 1eq. NaOH 33.34 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PPAR Products |
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SR1664 is an antidiabetic compound that binds to PPARγ and can effectively inhibit CDK5-mediated phosphorylation of PPARγ with IC50 of 80 nM and Ki of 28.67 nM. |
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WY 14643 (Pirinixic Acid) is a potent and selective, peroxisome proliferator-activated receptor-α (PPARα) agonist. |
| Rosiglitazone
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