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Cibisatamab

Cat. No. M24833

All AbMole products are for research use only, cannot be used for human consumption.

Cibisatamab Structure

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Quality Control & Documentation
Biological Activity

Cibisatamab (CEA-TCB), a T cell bispecific antibody, binds Carcino-Embryonic Antigen (CEA) on cancer cells and CD3 on T cells. Cibisatamab (CEA-TCB) triggers T cell killing of cancer cell lines expressing moderate to high levels of CEA at the cell surface. Cibisatamab (CEA-TCB) can be used for colorectal cancer research.

Chemical Information
CAS Number 1855925-27-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Samira Anbari, et al. Front Pharmacol. Using quantitative systems pharmacology modeling to optimize combination therapy of anti-PD-L1 checkpoint inhibitor and T cell engager

[2] Alvaro Teijeira, et al. Theranostics. Three-dimensional colon cancer organoids model the response to CEA-CD3 T-cell engagers

[3] Miro Julian Eigenmann, et al. Pharmaceutics. Pharmacokinetics and Pharmacodynamics of T-Cell Bispecifics in the Tumour Interstitial Fluid

[4] Arthur J Van De Vyver, et al. Mol Cancer Ther. Predicting Tumor Killing and T-Cell Activation by T-Cell Bispecific Antibodies as a Function of Target Expression: Combining In Vitro Experiments with Systems Modeling

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Keywords: Cibisatamab supplier, inhibitors, activators

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