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Cibinetide (ARA290) is an EPO-derivative, acting as a specific agonist of erythropoietin/CD131 heteroreceptor, and used for the research of neurological disease. Cibinetide (ARA290) enhances the proliferation, migration, and resistance to H2O2-induced apoptosis of endothelial colony-forming cells (ECFCs).
Cibinetide (ARA290; 30 μg/kg, s.c.) prevents progressive worsening of glucose control without affecting body weight of rats. Cibinetide significantly decreases glucose AUCs in IPGTT in GK rats. Low-dosage Cibinetide (35 μg/kg, i.p.) treatment only slightly attenuates the EAE severity in rats. Cibinetide-treating group (70 μg/kg, i.p.) significantly delays the onset, decreases the neurologic severity and shortens the duration of EAE in a dose-dependent way.
| Molecular Weight | 1257.31 |
| Formula | C51H84N16O21 |
| CAS Number | 1208243-50-8 |
| Solubility (25°C) | Water 50 mg/mL (adjust pH to 8 with NH3·H2O) 0.1 M NaOH: 50 mg/mL |
| Storage | -20°C, dry, sealed |
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