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Chromeceptin

Cat. No. M7685

All AbMole products are for research use only, cannot be used for human consumption.

Chromeceptin Structure
Size Price Availability Quantity
1mg USD 50 In stock
5mg USD 90 In stock
10mg USD 140 In stock
25mg USD 285 In stock
50mg USD 410 In stock
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Quality Control & Documentation
Biological Activity

Chromeceptin inhibits Insulin-like growth factor 2 (IGF2) signaling by a process that begins with chromeceptin binding to multifunctional protein 2 (MFP-2). This interaction stimulates the expression of IGF binding protein 1 (IGFBP-1) and suppressor of cytokine signaling-3 (SOCS-3), both of which activate signal transducers and activators of transcription 6 (STAT6) to attenuate IGF signals.

Chemical Information
Molecular Weight 359.35
Formula C19H16F3N3O
CAS Number 331859-86-0
Solubility (25°C) Water: <2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yantao Zhao, et al. Activation of Insulin-Like Growth Factor-2 Ameliorates Retinal Cell Damage and Exerts Protection in in vitro Model of Diabetic Retinopathy

[2] Hyang Sook Seol, et al. Loss of miR-100 and miR-125b results in cancer stem cell properties through IGF2 upregulation in hepatocellular carcinoma

[3] Dongju Jung, et al. Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule

[4] Motonari Uesugi. Control and analysis of cells by synthetic small molecules

[5] Ning Ma, et al. Coexpression of an intronic microRNA and its host gene reveals a potential role for miR-483-5p as an IGF2 partner

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Keywords: Chromeceptin supplier, IGF-1R, inhibitors, activators

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