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Chlorthalidone is a thiazide-like diuretic, it has potential for the research of hypertension. Chlorthalidone increases the excretion of sodium, chloride, and water into the renal lumen by inhibiting sodium ion transport across the renal tubular epithelium. Its primary site of action is in the cortical diluting segment of the ascending limb of the loop of Henle. By increasing the delivery of sodium to the distal renal tubule, chlorthalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism (i.e. apical ROMK/Na channels coupled with basolateral NKATPases).
| Molecular Weight | 338.77 |
| Formula | C14H11ClN2O4S |
| CAS Number | 77-36-1 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] David C Wheeler. Chlorthalidone in Advanced Chronic Kidney Disease - Have We Missed a Trick?
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