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Chlorpheniramine, a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
| Cell Experiment | |
|---|---|
| Cell lines | MCF-7, MDA-MB 231, and Ehrlich |
| Preparation method | Exposing cells to various concentrations of Chlorpheniramine for 48 hours. Cells are washed, detached, and counted with a Coulter counter to determine cell growth. |
| Concentrations | Dissolved in water, final concentrations ~500 μM |
| Incubation time | 48 hours |
| Animal Experiment | |
|---|---|
| Animal models | Male NC/Nga mice, male ICR mice and female BALB/c mice with atopic dermatitis |
| Formulation | Suspended in 1% (v/v) Tween 80 |
| Dosages | 10 mg/kg |
| Administration | Orally |
| Molecular Weight | 390.86 |
| Formula | C16H19ClN2.C4H4O4 |
| CAS Number | 113-92-8 |
| Solubility (25°C) | DMSO 70 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Histamine Receptor Products |
|---|
| Ciproxifan maleate
Ciproxifan is an orally bioavailable, extremely potent histamine H3 inverse agonist/antagonist. |
| Antazoline hydrochloride
Antazoline hydrochloride is a first generation antihistamine, binding to the histamine H1 receptor and blocking the action of endogenous histamine. |
| Azacyclonol
Azacyclonol, also known as γ-pipradol, which diminishes hallucinations in psychotic individuals. |
| Azatadine dimaleate
Azatadine dimaleate is an antihistamine and anticholinergic compound with IC50 of 6.5nM and 10nM, respectively. |
| Bepotastine Besilate
Bepotastine is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7. |
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